Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques

Nature Communications, Published online: 24 January 2026; doi:10.1038/s41467-025-65766-0

Neural mechanism underlying behavioural flexibility is not fully understood. Here authors study decision-making of macaques in a reversal task. They identify two complementary cognitive processes. Distinct neural patterns link these processes to the dorsomedial prefrontal cortex, thalamus, and hippocampus.

​Nature Communications, Published online: 24 January 2026; doi:10.1038/s41467-025-65766-0Neural mechanism underlying behavioural flexibility is not fully understood. Here authors study decision-making of macaques in a reversal task. They identify two complementary cognitive processes. Distinct neural patterns link these processes to the dorsomedial prefrontal cortex, thalamus, and hippocampus.