Molecular recognition of thyroglobulin by sortilin

Nature Communications, Published online: 24 January 2026; doi:10.1038/s41467-026-68658-z

Sortilin mediates thyroglobulin endocytosis within the thyroid. Using structural biology, the authors reveal that sortilin acts as structural sensor of monomeric thyroglobulin, independently of its iodination and hormone content, via binding of a flexible C-terminal peptide.

​Nature Communications, Published online: 24 January 2026; doi:10.1038/s41467-026-68658-zSortilin mediates thyroglobulin endocytosis within the thyroid. Using structural biology, the authors reveal that sortilin acts as structural sensor of monomeric thyroglobulin, independently of its iodination and hormone content, via binding of a flexible C-terminal peptide.