BiG-SCAPE 2.0 and BiG-SLiCE 2.0: scalable, accurate and interactive sequence clustering of metabolic gene clusters

Nature Communications, Published online: 24 January 2026; doi:10.1038/s41467-026-68733-5

BiG-SCAPE and BiG-SLiCE are computational tools that enable exploring the diversity of metabolic gene clusters across microbial genomes. Here, the authors present major updates to these tools, providing essential infrastructure for studying the diversity of microbial metabolism.

​Nature Communications, Published online: 24 January 2026; doi:10.1038/s41467-026-68733-5BiG-SCAPE and BiG-SLiCE are computational tools that enable exploring the diversity of metabolic gene clusters across microbial genomes. Here, the authors present major updates to these tools, providing essential infrastructure for studying the diversity of microbial metabolism.